Children around the world are facing COVID-19 and wars, which have brought huge impacts on life, psychology, and society. It's the first time that Jebb Care for Children (JECC) held the activity for children's rights initiative, starting with Jebb Eglantyne, the mother of children's rights, speaking for children, and introducing the concept "Effective Altruism" from Peter Singer, the father of philanthropy. We call on companies and people across the world to take effective humanitarian actions based on scientific evidence.

This study starts with clinically proven safe drugs and employs big data and AI to explore new applications against the novel coronavirus. The team simulated the binding of the COVID-19 virus with drugs to predict outcomes, creating the 'DockCoV2' database, which is made available to medical research teams worldwide as a reference for future experimental designs. We also utilized genetic drug data to investigate existing drugs with antiviral properties, which showed inhibitory effects at a concentration as low as 20 nanomoles in cellular tests

The international collaboration subproject has established a comprehensive framework for international cooperation and has created project research teams with international competitiveness on specific issues. Currently, the subproject has conducted multiple webinars on various topics and institutions and organized large-scale international hybrid online-offline seminars. In the establishment of internationally competitive project research teams, the subproject leader, Ms. Yun-Ru Huang, has collaborated with the National University of Singapore to establish an international partnership on 'COVID-19 in Pregnancy.' This collaboration aims to understand the mother-to-fetus transmission mechanism of SARS-CoV-2 and the immune barrier function of the human placenta. Research findings have been published, and Ms. Huang received the 2020 nanoString Pacific Spatial Biology Research Award from the U.S. nanoString company

The research team focuses on the development of antiviral drugs by targeting key host molecules that regulate virus infection and replication. They have discovered that the cellular Furin protease can cleave the Spike protein of the novel coronavirus, which is crucial for Spike-induced cell fusion (Syncytium). Further, targeting the Furin protease as a target for antiviral drug development, they have identified two Furin protease inhibitors. These inhibitors can effectively block virus entry into cells and inhibit viral RNA transcription, thus effectively suppressing the replication and cell fusion pathology induced by the novel coronavirus, including the D614G variant, in host cells. These findings serve as promising lead compounds for the subsequent development of potential anti-COVID-19 drugs.

Highlights of 2022: Promoting the Epidemic Prevention Science Research Center and Showcasing Project-related Achievements

We have developed an Immediate Monitoring Unveiling Index (Lifting Social Distancing, LSD) model based on reported COVID-19 confirmed cases, deaths, and recoveries in each country. This model helps determine the feasibility of lifting restrictions (with LSD<1 as the threshold) and the expected timeframe.